E50 Exosomes
- E50 exosomes – skin£250
- E50 exosomes – hair & scalp£300
- E50 exosomes – add-on after CO2 laser£120

E50 exosome therapy is a regenerative treatment in which bio-active exosomes, tiny vesicles that carry proteins, lipids and nucleic acids between cells, are applied to the skin or scalp straight after microneedling or CO2 laser. It aims to support skin renewal, calm inflammation and improve hair quality. It is available at Skin Anatomy in Southwell, Nottinghamshire.
Exosomes are one of the most talked-about developments in aesthetic skin science. They are tiny vesicles, far smaller than cells, that cells naturally release to communicate with one another. Each exosome carries a cargo of bio-molecules, including proteins, lipids and nucleic acids, that can influence how neighbouring cells behave. Research has explored their role in skin regeneration, hair growth and calming inflammation, which is why they are now used to support skin recovery and renewal. It is an emerging area, and research is ongoing.
Skin Anatomy now offers E50 exosome treatments for both skin rejuvenation and hair. E50 is a cosmetic product rather than a licensed medicine, and it comes in two versions: E50 Skin, designed to support skin renewal, texture and tone, and E50 Hair, designed for the scalp. Both are made using a proprietary process called ENTR® Technology, and both are fully salmon-derived, which is why we check carefully for fish allergies before treatment.
Exosomes work best when they can reach the living layers of the skin. At Skin Anatomy, E50 is applied to the skin or scalp straight after gentle microneedling, or as part of a fractional CO2 laser session, when the tiny micro-channels created by the treatment help absorption. Many clients add E50 to their CO2 laser resurfacing to support recovery and help calm post-laser redness, and it is a combination our clients have chosen when they want the most from their laser treatment.
Every plan starts with a free consultation in Southwell with Magdalena Wasiewicz, our Founder and Lead Aesthetic Practitioner. We look at your skin or scalp, discuss your goals and history and set realistic expectations. For thinning hair, we ask about the pattern and timing of any hair loss. Sudden, patchy or unexplained hair loss should always be checked by your GP first, as it can have a medical cause that needs investigation.
For skin, your face is cleansed and numbing cream is applied. We then perform gentle microneedling, creating thousands of tiny channels, and apply E50 Skin across the area so it can be absorbed. If you are having CO2 laser resurfacing, E50 is applied as part of that session instead. For hair, the scalp is cleansed, the thinning areas are microneedled and E50 Hair is worked into the scalp. Appointments usually take 45 to 60 minutes, including numbing time.
E50 exosomes are designed to support the skin's natural regeneration, which may improve texture, tone, radiance and the appearance of fine lines and pores. They can help calm redness and inflammation, which is why they are popular after CO2 laser to support a smoother recovery. On the scalp, E50 Hair aims to support a healthier environment for hair follicles, and some clients see thicker-looking hair over a course. Exosome treatments are an emerging area, and results vary from person to person.
Most side effects come from the microneedling or laser rather than the exosomes. Expect redness and warmth similar to mild sunburn for one to three days, with possible mild swelling, tenderness, dryness and pinpoint bleeding during treatment. Some people notice sensitivity or a few breakouts as the skin renews. Allergic reactions are rare, but E50 is salmon-derived and not suitable if you have a fish allergy. Infection is uncommon when aftercare is followed. We explain all risks before you consent.
After microneedling with E50, most clients have pink, slightly tight skin for one to three days and return to work within a day or two. Avoid make-up for 24 hours, and avoid exercise, swimming, saunas and active skincare for 48 to 72 hours. After a scalp treatment, avoid washing your hair for 24 hours. When E50 is added to CO2 laser, follow your CO2 aftercare plan, as recovery then follows the CO2 timeline of redness and rough, flaking skin before new skin appears around days 7 to 10.
Contact us if redness, swelling or pain is increasing rather than settling after 48 hours, if you notice yellow crusting, pus, blistering or spreading redness, or if you feel feverish or unwell, as these can be signs of infection. Please also tell us about any rash, itching or hives, which may indicate an allergic reaction. For difficulty breathing or swelling of the face, lips or throat, call 999 immediately. If hair loss suddenly worsens or becomes patchy, see your GP.


Treatments are for adults aged 18 and over. We check your medical history at your consultation and will always tell you honestly if a treatment isn’t right for you.
We confirm which areas are suitable for you at your free consultation.
We begin with a free consultation in Southwell. We examine your skin or scalp, take your medical history, check for fish allergies and discuss what E50 can and cannot realistically do. For hair concerns, we ask how long the thinning has been happening and whether it has been checked by your GP.
Stop retinoids, exfoliating acids and scrubs three to five days before a skin treatment, and avoid sunbeds and sunburn. Arrive without make-up if you can. For a scalp treatment, come with clean, dry hair and no styling products. If you are combining E50 with CO2 laser, follow your CO2 preparation plan.
Once the numbing cream has taken effect, we perform gentle microneedling and apply E50 Skin or E50 Hair so the exosomes can be absorbed through the micro-channels. If E50 is part of your CO2 session, it is applied after the laser. Your skin will look pink and feel warm afterwards.
You leave with clear aftercare instructions. Skin plans may be a single add-on session or a short course, while hair plans usually involve several sessions a few weeks apart, as hair growth takes time. We review your progress and photographs at each visit so we can see how you are responding.

E50 exosomes are made using a proprietary process called ENTR® Technology. For E50 Skin, exosomes are collected from salmon testes cells and cultivated in dermis stem cell media; for E50 Hair, they are cultivated in embryonic stem cell media. Both the cell host and the media are fully salmon-derived, which the manufacturer says keeps free radicals and impurities low. According to the manufacturer, ENTR® limits the doubling time of the harvested exosomes, producing a homogenous, pure product with up to 10,000-fold more exosomes per unit than other exosomes.
Before and after E50 Exosomes at Skin Anatomy. Drag the handle to compare. Photos are unretouched — individual results vary.






Every treatment starts with a free, no-obligation consultation. Prices include VAT; where a price is shown as “from”, your exact cost depends on your assessment and is confirmed before you book.
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Most side effects are mild and settle on their own. We explain every risk at your consultation and give you written aftercare. If you are worried after treatment, call us on 07777 711 277; for anything urgent, contact NHS 111, or 999 in an emergency.
Skin Anatomy is at 17 Queen Street, Southwell, Nottinghamshire NG25 0AA, around 30 minutes from Nottingham, 15 minutes from Newark-on-Trent and 25 minutes from Mansfield by car (approximate). Clients visit us for E50 Exosomes from Southwell and the surrounding villages, as well as Nottingham, Newark-on-Trent, Mansfield, Bingham and Ollerton. Find travel and parking tips for your town:
